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Palladium-Catalyzed Regio- and Enantioselective Hydrosulfonylation of 1,3-Dienes with Sulfinic Acids: Scope, Mechanism, and Origin of Selectivity

Qinglong Zhang, Dongfang Dong and Weiwei Zi*

*State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China, Email: zinankai.edu.cn

Q. Zhang, D. Dong, W. Zi, J. Am. Chem. Soc., 2020, 142, 15654-15660.

DOI: 10.1021/jacs.0c05976 (free Supporting Information)


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Abstract

A (R)-DTBM-Segphos/Pd-catalyzed regio- and enantioselective hydrosulfonylation of 1,3-dienes with sulfinic acids provides atom- and step-economical access to 1,3-disubstituted chiral allylic sulfones. The reaction occurs under mild conditions and has a broad substrate scope.

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Key Words

allyl sulfones


ID: J48-Y2020