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Sulfuryl Fluoride Promoted Thiocyanation of Alcohols: A Practical Method for Preparing Thiocyanates

Guofu Zhang, Lidi Xuan, Yiyong Zhao, Chengrong Ding*

*College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China, Email:

G. Zhang, L. Xuan, Y. Zhao, C. Ding, Synlett, 2020, 31, 1413-1417.

DOI: 10.1055/s-0040-1707151

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SO2F2 promotes a one-step synthesis of thiocyanates through C-O bond cleavage of readily available alcohols with ammonium thiocyanate as the thiocyanating agent. A borad range of alcohols reacted with high efficiency in ethyl acetate under mild conditions to afford the corresponding thiocyanates in very good yields with broad functional group compatibility.

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Key Words

sulfuryl fluoride catalysis, alcohols, thiocyanation, ammonium thiocyanate, thiocyanates

ID: J72-Y2020