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Access to β-Hydroxyl Esters via Copper-Catalyzed Reformatsky Reaction of Ketones and Aldehydes

Lu Ouyang, Jian Hua Liao, Yan Ping Xia, Ren Shi Luo*

*School of Pharmacy, Gannan Medical University, Ganzhou, 341000, Jiangxi Province, P. R. of China, Email:

L. Ouyang, J. H. Liao, Y. P. Xia, R. S. Luo, Synlett, 2020, 31, 1418-1422.

DOI: 10.1055/s-0040-1707110


An efficient and simple Cu-catalyzed Reformatsky reaction of carbonyl compounds with ethyl iodoacetate provides excellent yields of β-hydroxyl esters using inexpensive starting materials under mild reaction conditions.

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Key Words

Reformatsky reaction, copper catalysis, carbonyl compounds, β-hydroxy esters, manganese powder

ID: J72-Y2020