Organic Chemistry Portal

Abstracts

Search:

Iridium-Catalyzed C-Alkylation of Methyl Group on N-Heteroaromatic Compounds using Alcohols

Mitsuki Onoda and Ken-ichi Fujita*

*Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan, Email: fujita.kenichi.6akyoto-u.ac.jp

M. Onoda, K.-i. Fujita, Org. Lett., 2020, 22, 7230-7233.

DOI: 10.1021/acs.orglett.0c02635


see article for more reactions

Abstract

[Cp*IrCl2]2 catalyzes a C-alkylation of a methyl group on N-heteroaromatic compounds, including pyridines, pyrimidines, pyrazines, quinolines, quinoxalines, and isoquinolines, with alcohols in the presence of potassium t-butoxide and 18-crown-6-ether.

see article for more examples



Key Words

pyrazines


ID: J54-Y2020