Facile Approach to Geminal Heterodihalogenation. One-Pot Synthesis of α-Bromo-α-Chloro Ketones
Jin-feng Zhou, Dong-min Tang, Ming Bian*
*School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, P. R. China,
Email: bianming
sit.edu.cn
J.-f. Zhou, D.-m. Tang, M. Bian, Synlett, 2020, 31, 1430-1434.
DOI: 10.1055/s-0040-1707169
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Abstract
The combination of dimethyl sulfoxide, HCl, and HBr enables a mild, efficient, and practical geminal heterodihalogenation of methyl ketones. This convenient method might be useful for the assembly of bromochloromethyl groups in drug discovery.
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Key Words
heterodihalogenation, dimethyl sulfoxide, α-bromo ketones, α-chloro ketones, tandem reaction
ID: J72-Y2020
