Synthesis of Hydroxamic Acid Derivatives Using Blocked (Masked) O-Isocyanate Precursors
Joshua S. Derasp, Erica A. Barbera, Niève R. Séguin, David D. Brzezinski and André M. Beauchemin*
*Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie-Curie, Ottawa, Ontario K1N 6N5, Canada,
Email: andre.beauchemin
uottawa.ca
J. S. Derasp, E. A. Barbera, N. R. Séguin, D. D. Brzezinski, A. M. Beauchemin, Org. Lett., 2020, 22, 7403-7407.
DOI: 10.1021/acs.orglett.0c02782
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Abstract
A reaction of unactivated carboxylic acids with masked O-substituted isocyanates provides hydroxamates. This method offers broad functional group tolerance.
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proposed reaction pathway
Key Words
ID: J54-Y2020
