Organic Chemistry Portal



Synthesis of Hydroxamic Acid Derivatives Using Blocked (Masked) O-Isocyanate Precursors

Joshua S. Derasp, Erica A. Barbera, Niève R. Séguin, David D. Brzezinski and André M. Beauchemin*

*Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie-Curie, Ottawa, Ontario K1N 6N5, Canada, Email:

J. S. Derasp, E. A. Barbera, N. R. Séguin, D. D. Brzezinski, A. M. Beauchemin, Org. Lett., 2020, 22, 7403-7407.

DOI: 10.1021/acs.orglett.0c02782

see article for more reactions


A reaction of unactivated carboxylic acids with masked O-substituted isocyanates provides hydroxamates. This method offers broad functional group tolerance.

see article for more examples

proposed reaction pathway

Key Words


ID: J54-Y2020