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CuI/2-Aminopyridine 1-Oxide Catalyzed Amination of Aryl Chlorides with Aliphatic Amines

Wenjie Liu, Jiamin Xu, Xiahong Chen, Fuxing Zhang, Zhifeng Xu, Deping Wang*, Yongqiang He, Xiaohong Xia*, Xin Zhang and Yun Liang*

*Hengyang Normal University, Hengyang 421008; Hunan University, Changsha 410082; Hunan Normal University, Changsha 410081, PR China, Email:,,

W. Liu, J. Xu, X. Chen, F. Zhang, Z. Xu, D. Wang, Y. He, X. Xia, X. Zhang, Y. Liang, Org. Lett., 2020, 22, 7486-7490.

DOI: 10.1021/acs.orglett.0c02672

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2-aminopyridine 1-oxides are effective ligands for Cu-catalyzed amination of less reactive (hetero)aryl chlorides with aliphatic amines. A wide range of functionalized (hetero)aryl chlorides reacted with various primary and cyclic secondary amines to afford the desired products in good to excellent yields.

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Key Words

Ullmann reaction, amination

ID: J54-Y2020