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Synthesis of Polysubstituted Pyrroles via Silver-Catalyzed Oxidative Radical Addition of Cyclopropanols to Imines

Yulu Zhou, Mingchang Wu, Yi Liu, Cungui Cheng and Gangguo Zhu*

*Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P.R. China, Email: gangguozjnu.cn

Y. Zhou, M. Wu, Y. Liu, C. Cheng, G. Zhu, Org. Lett., 2020, 22, 7542-7546.

DOI: 10.1021/acs.orglett.0c02735 (free Supporting Information)


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Abstract

A silver-catalyzed formal [3 + 2] cycloaddition reaction, with cyclopropanols as a C3 subunit and imines as a two-atom subunit, takes place under mild conditions and produces a broad array of polysubstituted pyrroles in good yields.


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Key Words

pyrroles, ammonium peroxydisulfate


ID: J54-Y2020