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Synthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using Amines with CF3SO2Cl

Jingjing Wei, Shuaishuai Liang, Lvqi Jiang* and Wenbin Yi*

*School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China, Email:,

J. Wei, S. Liang, L. Jiang, W. Yi, J. Org. Chem., 2020, 85, 12374-12381.

DOI: 10.1021/acs.joc.0c01903

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In the presence of trifluoromethanesulfonyl chloride, triphenylphosphine, and sodium iodide, a broad range of thiocarbamyl fluorides and isothiocyanates can be synthesized from secondary and primary amines in good yields, respectively. The reactions offer good functional group compatibility.

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Key Words

Thiocarbamoyl Fluorides, Isothiocyanates, Triphenylphosphine

ID: J42-Y2020