Synthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using Amines with CF3SO2Cl
Jingjing Wei, Shuaishuai Liang, Lvqi Jiang* and Wenbin Yi*
*School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China, Email: lvqi.jiangnjust.edu.cn, yiwbnjust.edu.cn
J. Wei, S. Liang, L. Jiang, W. Yi, J. Org. Chem., 2020, 85, 12374-12381.
see article for more reactions
In the presence of trifluoromethanesulfonyl chloride, triphenylphosphine, and sodium iodide, a broad range of thiocarbamyl fluorides and isothiocyanates can be synthesized from secondary and primary amines in good yields, respectively. The reactions offer good functional group compatibility.
see article for more examples
Thiocarbamoyl Fluorides, Isothiocyanates, Triphenylphosphine