Synthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using Amines with CF3SO2Cl
Jingjing Wei, Shuaishuai Liang, Lvqi Jiang* and Wenbin Yi*
*School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China, Email: lvqi.jiangnjust.edu.cn, yiwbnjust.edu.cn
J. Wei, S. Liang, L. Jiang, W. Yi, J. Org. Chem., 2020, 85, 12374-12381.
DOI: 10.1021/acs.joc.0c01903 (free Supporting Information)
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In the presence of trifluoromethanesulfonyl chloride, triphenylphosphine, and sodium iodide, a broad range of thiocarbamyl fluorides and isothiocyanates can be synthesized from secondary and primary amines in good yields, respectively. The reactions offer good functional group compatibility.
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