Oxetane Intermediate during a Direct Aldol Reaction: Stereoselective [5 + 1] Annulation Affording Tetralines
Takeshi Kuri, Yoshihiko Mizukami, Mio Shimogaki and Morifumi Fujita*
*Graduate School of Material Science, University of Hyogo, Kohto, Kamigori, Hyogo 678-1297, Japan, Email: fujisci.u-hyogo.ac.jp
T. Kuri, Y. Mizukami, M. Shimogaki, M. Fujita, Org. Lett., 2020, 22, 7613-7616.
DOI: 10.1021/acs.orglett.0c02816 (free Supporting Information)
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An oxetane intermediate during a direct aldol reaction can be trapped with an internal aryl group to yield trans-tetraline products.
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proposed reaction pathway