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Oxetane Intermediate during a Direct Aldol Reaction: Stereoselective [5 + 1] Annulation Affording Tetralines

Takeshi Kuri, Yoshihiko Mizukami, Mio Shimogaki and Morifumi Fujita*

*Graduate School of Material Science, University of Hyogo, Kohto, Kamigori, Hyogo 678-1297, Japan, Email: fujisci.u-hyogo.ac.jp

T. Kuri, Y. Mizukami, M. Shimogaki, M. Fujita, Org. Lett., 2020, 22, 7613-7616.

DOI: 10.1021/acs.orglett.0c02816 (free Supporting Information)


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Abstract

An oxetane intermediate during a direct aldol reaction can be trapped with an internal aryl group to yield trans-tetraline products.


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proposed reaction pathway



Key Words

benzocyclohexenes


ID: J54-Y2020