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An Efficient Copper-Catalyzed C(sp2)-S Formation Starting from Aryl Iodides and Tetramethylthiuram Monosulfide (TMTM)

Yue-Xiao Wu, Kang Peng, Jing-Hang Li, Zhi-Bing Dong*

*Hubei Key Laboratory of Novel Reactor and Green Chemistry Technology, Wuhan Institute of Technology, Wuhan 430205, P. R. of China, Email:

Y.-X. Wu, K. Peng, J.-H. Li, Z.-B. Dong, Synthesis, 2020, 52, 3001-3006.

DOI: 10.1055/s-0040-1707899 (free Supporting Information)


An efficient copper-catalyzed C(sp2)-S formation between aryl iodides and tetramethylthiuram monosulfide (TMTM) provides aryl dithiocarbamates in good to excellent yields. The high yields, decent functional group compatibility, and cost-effective substrates make this convenient protocol attractive for C-S bond formation.

see article for more examples

A Highly Efficient CuCl2-Catalyzed C-S Coupling of Aryl Iodides with Tetraalkylthiuram Disulfides: Synthesis of Aryl Dithiocarbamates

Q. Cao, H.-Y. Peng, Y. Cheng, Z.-B. Dong, Synthesis, 2018, 50, 1527-1534.

Copper-Catalyzed C(sp2)-S Coupling Reactions for the Synthesis of Aryl Dithiocarbamates with Thiuram Disulfide Reagents

Z.-B. Dong, X. Liu, C. Bolm, Org. Lett., 2017, 19, 5916-5919.

Key Words

aryl iodides, thiurams, dithiocarbamates

ID: J66-Y2020