An Efficient Copper-Catalyzed C(sp²)-S Formation Starting from Aryl Iodides and Tetramethylthiuram Monosulfide (TMTM)

Yue-Xiao Wu, Kang Peng, Jing-Hang Li, Zhi-Bing Dong*

*Hubei Key Laboratory of Novel Reactor and Green Chemistry Technology, Wuhan Institute of Technology, Wuhan 430205, P. R. of China, Email: dzb04982wit.edu.cn

Y.-X. Wu, K. Peng, J.-H. Li, Z.-B. Dong, Synthesis, 2020, 52, 3001-3006.

DOI: 10.1055/s-0040-1707899

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Abstract

An efficient copper-catalyzed C(sp²)-S formation between aryl iodides and tetramethylthiuram monosulfide (TMTM) provides aryl dithiocarbamates in good to excellent yields. The high yields, decent functional group compatibility, and cost-effective substrates make this convenient protocol attractive for C-S bond formation.

see article for more examples

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A Highly Efficient CuCl₂-Catalyzed C-S Coupling of Aryl Iodides with Tetraalkylthiuram Disulfides: Synthesis of Aryl Dithiocarbamates

Q. Cao, H.-Y. Peng, Y. Cheng, Z.-B. Dong, Synthesis, 2018, 50, 1527-1534.

Copper-Catalyzed C(sp²)-S Coupling Reactions for the Synthesis of Aryl Dithiocarbamates with Thiuram Disulfide Reagents

Z.-B. Dong, X. Liu, C. Bolm, Org. Lett., 2017, 19, 5916-5919.

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Key Words

aryl iodides, thiurams, dithiocarbamates

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ID: J66-Y2020