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Copper-Catalyzed Anti-Markovnikov Hydrosilylation of Terminal Alkynes

Zi-Lu Wang, Feng-Lian Zhang, Jian-Lin Xu, Cui-Cui Shan, Meng Zhao and Yun-He Xu*

*Department of Chemistry and Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230026, China, Email: xyh0709ustc.edu.cn

Z.-Lu Wang, F.-L. Zhang, J.-L. Xu, C.-C. Shan, M. Zhao, Y.-H. Xu, Org. Lett., 2020, 22, 7735-7742.

DOI: 10.1021/acs.orglett.0c02952 (free Supporting Information)



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Abstract

A copper-catalyzed anti-Markovnikov hydrosilylation of alkynes with PhSiH3 offers excellent recognition between terminal and internal triple bonds. Various (hetero)aromatic and aliphatic substituted terminal alkynes provides (E)-vinylsilanes in high yields and with excellent regioselectivity.

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Key Words

vinyl silanes


ID: J54-Y2020