Decarboxylative and Deaminative Alkylation of Difluoroenoxysilanes via Photoredox Catalysis: A General Method for Site-Selective Synthesis of Difluoroalkylated Alkanes
Heng Song, Ran Cheng, Qiao-Qiao Min and Xingang Zhang*
*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China,
Email: xgzhang
mail.sioc.ac.cn
H. Song, R. Cheng, Q.-Q. Min, X. Zhang, Org. Lett., 2020, 22, 7747-7751.
DOI: 10.1021/acs.orglett.0c02997
see article for more reactions
Abstract
A general site-selective difluoroalkylation of alkyl carboxylic redox esters with difluoroenoxysilanes through photoredox-catalyzed decarboxylation offers high efficiency, mild reaction conditions, and broad substrate scope. The reaction tolerates primary, secondary, and sterically hindered tertiaryl alkyl substrates and can also be extended to aliphatic amine derived pyridinium salts.
see article for more examples
While ads financed 62% of the published abstracts in 2024, donations allowed us to publish additional 12%. 26% of the abstracts have been published voluntarly. If you kindly donate, we can publish more freely accessible information and help the chemical community even more:
If you don't like pawalls or a flood of more and more advertising, then you can send a clear signal here!
Key Words
fluoroketones, alkylation, photochemistry
ID: J54-Y2020
