Stereoselective Construction of γ-Lactams via Copper-Catalyzed Borylacylation
Alexa Torelli, Andrew Whyte, Iuliia Polishchuk, Jonathan Bajohr and Mark Lautens*
*Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada,
Email: mark.lautens
utoronto.ca
A. Torelli, A. Whyte, I. Polishchuk, J. Bajohr, M. Lautens, Org. Lett., 2020, 22, 7915-7919.
DOI: 10.1021/acs.orglett.0c02837
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Abstract
A versatile and highly stereoselective borylative cyclization provides polyfunctionalized γ-lactams. The reaction system enables the construction of di- and trisubstituted γ-lactam cores, with examples containing enantioenriched quaternary carbons.
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Key Words
ID: J54-Y2020
