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Copper-Catalyzed Aerobic Cyclization of β,γ-Unsaturated Hydrazones with Concomitant C=C Bond Cleavage

Zhenwei Fan, Jiahao Feng, Yuchen Hou, Min Rao and Jiajia Cheng*

*College of Chemistry, Fuzhou University, Fuzhou 350116, China, Email:

Z. Fan, J. Feng, Y. Hou, M. Rao, J. Cheng, Org. Lett., 2020, 22, 7981-7985.

DOI: 10.1021/acs.orglett.0c02911

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A mild and convenient Cu-catalyzed aerobic oxidative cyclization of β,γ-unsaturated hydrazones provides a broad range of pyrazole derivatives. The reaction is initiated by the formation of a hydrazonyl radical, followed by cyclization and a concomitant C=C bond cleavage.

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proposed reaction pathway

Key Words

pyrazoles, oxygen

ID: J54-Y2020