Streamlined Catalytic Enantioselective Synthesis of α-Substituted β,γ-Unsaturated Ketones and Either of the Corresponding Tertiary Homoallylic Alcohol Diastereomers
Juan del Pozo, Shaochen Zhang, Filippo Romiti, Shibo Xu, Ryan P. Conger and Amir H. Hoveyda*
*Supramolecular Science and Engineering Institute, University of Strasbourg, CNRS, 67000 Strasbourg, France, Email: ahoveydaunistra.fr
J. del Pozo, S. Zhang, F. Romiti, S. Xu, R. P. Conger, A. H. Hoveyda, J. Am. Chem. Soc., 2020, 142, 18200-18212.
DOI: 10.1021/jacs.0c08732
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Abstract
Commercially available chiral ligands enable a widely applicable, practical, and scalable strategy for efficient and enantioselective synthesis of β,γ-unsaturated ketones that contain an α-stereogenic center.
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ligand
Key Words
allyl ketones, vinylboronates, multicomponent reactions
ID: J48-Y2020