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Streamlined Catalytic Enantioselective Synthesis of α-Substituted β,γ-Unsaturated Ketones and Either of the Corresponding Tertiary Homoallylic Alcohol Diastereomers

Juan del Pozo, Shaochen Zhang, Filippo Romiti, Shibo Xu, Ryan P. Conger and Amir H. Hoveyda*

*Supramolecular Science and Engineering Institute, University of Strasbourg, CNRS, 67000 Strasbourg, France, Email: ahoveydaunistra.fr

J. del Pozo, S. Zhang, F. Romiti, S. Xu, R. P. Conger, A. H. Hoveyda, J. Am. Chem. Soc., 2020, 142, 18200-18212.

DOI: 10.1021/jacs.0c08732


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Abstract

Commercially available chiral ligands enable a widely applicable, practical, and scalable strategy for efficient and enantioselective synthesis of β,γ-unsaturated ketones that contain an α-stereogenic center.

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ligand



Key Words

allyl ketones, vinylboronates, multicomponent reactions


ID: J48-Y2020