Organic Chemistry Portal



Synthesis of α-Aminophosphonates via Phosphonylation of an Aryne-Imine Adduct

Taehyun Lim and Byeong Moon Kim*

*Department of Chemistry, College of Natural Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea, Email:

T. Lim, B. M. Kim, J. Org. Chem., 2020, 85, 13037-13049.

DOI: 10.1021/acs.joc.0c01410

see article for more reactions


The reaction of an imine with an aryne generated in situ in the presence of a dialkyl phosphite provides α-aminophosphonates in good yields. This transition-metal-free multicomponent phosphonylation shows a broad substrate scope.

see article for more examples

Key Words

phosphonylation, arylation, multicomponent reactions

ID: J42-Y2020