B(C₆F₅)₃-Catalyzed Highly Chemoselective Reduction of Isatins: Synthesis of Indolin-3-ones and Indolines

Hyojin Jeong, Nara Han, Dong Wook Hwang and Haye Min Ko*

*Department of Chemistry, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea, Email: hayeminkowku.ac.kr

H. Jeong, N. Han, D. W. Hwang, H. M. Ko, Org. Lett., 2020, 22, 8096-8100.

DOI: 10.1021/acs.orglett.0c03150

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Abstract

Efficient and operationally simple reactions using a combination of B(C₆F₅)₃ and BnMe₂SiH or B(C₆F₅)₃ and Et₂SiH₂ provide various indolin-3-ones and indolines under mild conditions, without the need for multistep procedures and metal catalysts.

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Key Words

indolin-3-ones, silanes

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ID: J54-Y2020