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General Synthesis of α-Alkyl Ynones from Morpholine Amides and 1-Copper(I) Alkynes Promoted by Triflic Anhydride

Yunxiang Weng, Lin Min, Xiaobao Zeng, Lidong Shan, Xinyan Wang* and Yuefei Hu*

*Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China, Email:,

Y. Weng, L. Min, X. Zeng, L. Shan, X. Wang, Y. Hu, Org. Lett., 2020, 22, 8296-8301.

DOI: 10.1021/acs.orglett.0c02944

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A general method for the synthesis of α-alkyl ynones is based on the strategy of electrophilic activation of amides. Its distinctive advantages are attributed to the use of air-stable 1-copper(I) alkynes as mild nucleophiles without any exogeneous ligand.

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ID: J54-Y2020