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NHC/Copper-Cocatalyzed [4 + 3] Annulations of Salicylaldehydes with Aziridines for the Synthesis of 1,4-Benzoxazepinones

You-Feng Han, Zhong-Hua Gao, Chun-Lin Zhang* and Song Ye*

*Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China, Email:,

Y.-F. Han, Z.-H. Gao, C.-L. Zhang, S. Ye, Org. Lett., 2020, 22, 8396-8400.

DOI: 10.1021/acs.orglett.0c03026

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N-heterocyclic carbene/copper-cocatalyzed [4 + 3] annulations of salicylaldehydes with aziridines provide the corresponding 1,4-benzoxazepinones in good yields with exclusive regioselectivity.

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Key Words

benzo-fused O-heterocycles, benzo-fused N-heterocycles, 3,3',5,5'-tetra-tert-butyldiphenoquinone, DPQ

ID: J54-Y2020