Synthesis of α-Amidoketones through the Cascade Reaction of Carboxylic Acids with Vinyl Azides under Catalyst-Free Conditions
Cai Gao, Qianting Zhou, Li Yang, Xinying Zhang* and Xuesen Fan*
*School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China,
Email: xinyingzhang
htu.cn, xuesen.fanhtu.cn
C. Gao, Q. Zhou, X. Zhang, X. Fan, J. Org. Chem., 2020, 85, 13710-13720.
DOI: 10.1021/acs.joc.0c01871
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Abstract
A cascade reaction of carboxylic acids with vinyl azides enables an efficient synthesis of α-amidoketone derivatives. This method offers catalyst-free conditions, broad substrate scope, good tolerance of a wide range of functional groups, and high efficiency.
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proposed mechanism
Key Words
ID: J42-Y2020
