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Palladium-Catalyzed Hydroxylation of Aryl Halides with Boric Acid

Zhi-Qiang Song and Dong-Hui Wang*

*University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China, Email: dhwangsioc.ac.cn

Z.-Q. Song, D.-H. Wang, Org. Lett., 2020, 22, 8470-8474.

DOI: 10.1021/acs.orglett.0c03069


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Abstract

Boric acid, B(OH)3, is an efficient hydroxide reagent in a Pd-catalyzed conversion of (hetero)aryl halides to the corresponding phenols in very good yields under mild conditions. This transformation tolerates a broad range of functional groups.

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Key Words

phenols


ID: J54-Y2020