Direct Enantioselective C(sp³)-H Acylation for the Synthesis of α-Amino Ketones

Xiaomin Shu, Leitao Huan, Qian Huang and Haohua Huo*

*College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China, Email: hhuoxmu.edu.cn

X. Shu, L. Huan, Q. Huang, H. Huo, J. Am. Chem. Soc., 2020, 142, 18310-18316.

DOI: 10.1021/jacs.0c10471

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Abstract

The merger of transition metal and photoredox catalysis enables a direct enantioselective acylation of α-amino C(sp³)-H bonds with carboxylic acids to produce highly valuable α-amino ketones in high enantioselectivities under mild conditions.

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Key Words

α-Amino Ketones, Photochemistry

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ID: J48-Y2020