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Nickel-Catalyzed trans-Carboamination across Internal Alkynes to Access Multifunctionalized Indoles

Shrikant D. Tambe, Naeem Iqbal and Eun Jin Cho*

*Department of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea, Email: ejchocau.ac.kr

S. D. Tambe, N. Iqbal, E. J. Cho, Org. Lett., 2020, 22, 8550-8554.

DOI: 10.1021/acs.orglett.0c03148 (free Supporting Information)


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Abstract

A Ni-catalyzed trans-carboamination enables the synthesis of multifunctionalized indoles from 2-alkynylanilinoacrylates. Notably, the synthesized indoles could be successfully transformed to functionalized carbazoles.


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Key Words

indoles


ID: J54-Y2020