Electrochemical Synthesis of Quinazolinones by the Metal-Free and Acceptor-Free Dehydrogenation of 2-Aminobenzamides
Yan Yao, Xiu-Jin Meng, Qing-Hu Teng*, Yan-Yan Chen*
*School of Chemistry and Pharmaceutical Sciences, Guangxi
Normal University, Guilin 541004; Pharmacy School, Guilin Medical University,
Guilin 541004, P. R. of China, Email: qinghuteng
163.com;
chenyy269614@163.com
Y. Yao, X.-J. Meng, Q.-H. Teng, Y.-Y. Chen, Synlett, 2020, 31, 1795-1799.
DOI: 10.1055/s-0040-1707248
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Abstract
An efficient anodic dehydrogenative oxidation/cyclization of benzylic chlorides and 2-aminobenzamides selectively provides quinazolin-4(3H)-ones in good yields.
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Key Words
quinazolinones, electrochemistry, aminobenzamides, benzylic chlorides, metal-free
ID: J72-Y2020
