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A Series of Deoxyfluorination Reagents Featuring OCF2 Functional Groups

Shiyu Zhao, Yong Guo*, Zhaoben Su, Wei Cao, Chengying Wu and Qing-Yun Chen*

*Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China, Email:,

S. Zhao, Y. Guo, Z. Su, W. Cao, C. Wu, Q.-Y. Chen, Org. Lett., 2020, 22, 8634-8637.

DOI: 10.1021/acs.orglett.0c03238

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Perfluoroalkyl ether carboxylic acids (PFECAs) are alternatives for perfluoroalkyl substances with the goal of protecting the environment. PFECAs decompose to carbonic difluoride (COF2), which can be used for deoxyfluorination reactions of alcohols to provide alkyl fluorides in very good yields.

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proposed reaction pathway

Key Words

alkyl fluorides

ID: J54-Y2020