A Series of Deoxyfluorination Reagents Featuring OCF₂ Functional Groups

Shiyu Zhao, Yong Guo*, Zhaoben Su, Wei Cao, Chengying Wu and Qing-Yun Chen*

*Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China, Email: yguosioc.ac.cn, chenqysioc.ac.cn

S. Zhao, Y. Guo, Z. Su, W. Cao, C. Wu, Q.-Y. Chen, Org. Lett., 2020, 22, 8634-8637.

DOI: 10.1021/acs.orglett.0c03238

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Abstract

Perfluoroalkyl ether carboxylic acids (PFECAs) are alternatives for perfluoroalkyl substances with the goal of protecting the environment. PFECAs decompose to carbonic difluoride (COF₂), which can be used for deoxyfluorination reactions of alcohols to provide alkyl fluorides in very good yields.

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proposed reaction pathway

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Key Words

alkyl fluorides

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ID: J54-Y2020