Organic Chemistry Portal



A Practical Approach for the Transamidation of N,N-Dimethyl Amides with Primary Amines Promoted by Sodium tert-Butoxide under Solvent-Free Conditions

Rui Zhang, Jun-Chao Zhang, Wei-Yi Zhang, Yu-Qing He, Hua Cheng*, Cheng Chen*, Yu-Cheng Gu

*Hubei University of Arts and Science, Xiangyang 441053; Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, P. R. of China, Email:,

R. Zhang, J.-C. Zhang, W.-Y. Zhang, Y.-Q. He, H. Cheng, C. Chen, Y.-C. Gu, Synthesis, 2020, 52, 3286-3294.

DOI: 10.1055/s-0040-1705892

see article for more reactions


Sodium tert-butoxide mediates a transamidation of various N,N-dimethyl amides with primary amines to afford the corresponding amides in moderate to good yields at room temperature under solvent-free conditions. This protocol features a facile work-up procedure and good functional group compatibility.

see article for more examples

Key Words

NaOtBu, transamidation, N,N-dimethyl amides, primary amines, solvent-free, gram-scale

ID: J66-Y2020