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O-Benzoylhydroxylamines as Alkyl Nitrene Precursors: Synthesis of Saturated N-Heterocycles from Primary Amines

Hidetoshi Noda*, Yasuko Asada, Masakatsu Shibasaki*

*Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan, Email:,

H. Noda, Y. Asada, M. Shibasaki, Org. Lett., 2020, 22, 8769-8773.

DOI: 10.1021/acs.orglett.0c02842

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The combination of readily available and stable O-benzoylhydroxylamines as alkyl nitrene precursors and a proficient rhodium catalyst provides various pyrrolidines in very good yields.

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Key Words


ID: J54-Y2020