Carbamoyl Fluoride-Enabled Enantioselective Ni-Catalyzed Carbocarbamoylation of Unactivated Alkenes
Yue Li, Feng-Ping Zhang, Rong-Hua Wang, Shao-Long Qi, Yu-Xin Luan* and Mengchun Ye*
*State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China, Email: yxluannankai.edu.cn, mcyenankai.edu.cn
Y. Li, F.-P. Zhang, R.-H. Wang, S.-L. Qi, Y.-X. Luan, M. Ye, J. Am. Chem. Soc., 2020, 142, 19844-19849.
DOI: 10.1021/jacs.0c09949
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Abstract
A carbamoyl fluoride-enabled enantioselective Ni-catalyzed carbocarbamoylation of unactivated alkenes provides a broad range of chiral γ-lactams bearing an all-carbon quaternary center in good yield and high enantioselectivity.
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proposed mechanism
(R)-BINAP
Key Words
ID: J48-Y2020