Organic Chemistry Portal



Carbamoyl Fluoride-Enabled Enantioselective Ni-Catalyzed Carbocarbamoylation of Unactivated Alkenes

Yue Li, Feng-Ping Zhang, Rong-Hua Wang, Shao-Long Qi, Yu-Xin Luan* and Mengchun Ye*

*State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China, Email:,

Y. Li, F.-P. Zhang, R.-H. Wang, S.-L. Qi, Y.-X. Luan, M. Ye, J. Am. Chem. Soc., 2020, 142, 19844-19849.

DOI: 10.1021/jacs.0c09949

see article for more reactions


A carbamoyl fluoride-enabled enantioselective Ni-catalyzed carbocarbamoylation of unactivated alkenes provides a broad range of chiral γ-lactams bearing an all-carbon quaternary center in good yield and high enantioselectivity.

see article for more examples

proposed mechanism


Key Words


ID: J48-Y2020