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Nickel-Catalyzed Three-Component Reductive Alkylacylation of Electron-Deficient Activated Alkenes

Lin Wang and Chuan Wang*

*Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China, Email:

L. Wang, C. Wang, Org. Lett., 2020, 22, 8829-8835.

DOI: 10.1021/acs.orglett.0c03210

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A nickel-catalyzed three-component reductive alkylacylation of electron-deficient activated alkenes with acid anhydrides and tertiary alkyl bromides enables the efficient preparation of a variety of ketones with broad substrate scope and high functionality tolerance starting from simple precursors.

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Key Words

carbonylation, 1,4-addition, multicomponent reactions, zinc

ID: J54-Y2020