Organic Chemistry Portal

Abstracts

Search:

Nickel-Catalyzed Three-Component Reductive Alkylacylation of Electron-Deficient Activated Alkenes

Lin Wang and Chuan Wang*

*Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China, Email: chuanwustc.edu.cn

L. Wang, C. Wang, Org. Lett., 2020, 22, 8829-8835.

DOI: 10.1021/acs.orglett.0c03210 (free Supporting Information)


see article for more reactions

Abstract

A nickel-catalyzed three-component reductive alkylacylation of electron-deficient activated alkenes with acid anhydrides and tertiary alkyl bromides  enables the efficient preparation of a variety of ketones with broad substrate scope and high functionality tolerance starting from simple precursors.


see article for more examples



Key Words

carbonylation, 1,4-addition, multicomponent reactions, zinc


ID: J54-Y2020