Nickel-Catalyzed Three-Component Reductive Alkylacylation of Electron-Deficient Activated Alkenes
Lin Wang and Chuan Wang*
*Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China,
Email: chuanw
ustc.edu.cn
L. Wang, C. Wang, Org. Lett., 2020, 22, 8829-8835.
DOI: 10.1021/acs.orglett.0c03210
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Abstract
A nickel-catalyzed three-component reductive alkylacylation of electron-deficient activated alkenes with acid anhydrides and tertiary alkyl bromides enables the efficient preparation of a variety of ketones with broad substrate scope and high functionality tolerance starting from simple precursors.
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Key Words
carbonylation, 1,4-addition, multicomponent reactions, zinc
ID: J54-Y2020
