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An Efficient Hydration and Tandem Transfer Hydrogenation of Alkynes for the Synthesis of Alcohol in Water

Nianhua Luo, Yuhong Zhong, Ji-Tian Liu, Lu Ouyang*, Renshi Luo*

*School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, Jiangxi Province, P. R. of China, Email:,

N. Luo, Y. Zhong, J.-T. Liu, L. Ouyang, R. Luo, Synthesis, 2020, 52, 3439-3445.

DOI: 10.1055/s-0040-1707233

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A formic acid promoted hydration of readily available alkynes followed by an iridium-catalyzed transfer hydrogenation under mild conditions provides alcohols. This transformation is simple, efficient, and can be performed with a variety of alkynes in good yields and with excellent stereoselectivities.

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Key Words

hydration of alkynes, reduction of carbonyl compounds, benzylic alcohols, formic acid

ID: J66-Y2020