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Decarboxylative C-H Alkylation of Heteroarene N-Oxides by Visible Light/Copper Catalysis

Duan-Yang Liu, Xu Liu, Yan Gao, Chao-Qun Wang, Jie-Sheng Tian* and Teck-Peng Loh*

*Nanjing Tech University (NanjingTech), Nanjing 211816, P. R. China; Nanyang Technological University, Singapore 637371, Email:,

D.-Y. Liu, X. Liu, Y. Gao, C.-Q. Wang, J.-S. Tian, T.-P. Loh, Org. Lett., 2020, 22, 8978-8983.

DOI: 10.1021/acs.orglett.0c03382

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The use of hypervalent iodine(III) carboxylates as alkylating agents enables a highly site-selective alkylation of heteroarene N-oxides the presence of a cheap copper catalyst under visible light conditions. This mild method proceeds at room temperature in an air atmosphere.

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BPhen (Bathophenanthroline)

Key Words


ID: J54-Y2020