Evaluation and Development of Methodologies for the Synthesis of Thiophosphinic Acids
Karen R. Winters and Jean-Luc Montchamp*
*Department of Chemistry, Texas Christian University, PO Box 298860, Fort Worth, Texas 76129, United States,
Email: j.montchamp
tcu.edu
K. R. Winters, J.-L. Montchamp, J. Org. Chem., 2020, 85, 14545-14558.
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Abstract
For the synthesis of thiophosphinic acids, two major approaches were selected: (1) the Stec reaction of phosphorus amides with carbon disulfide; and (2) the one-pot synthesis of thiophosphorus acids from H-phosphinates, an organometallic nucleophile, and quenching with elemental sulfur. An application to the preparation of a potential chiral phosphorus organocatalyst is also reported.
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proposed mechanism
Key Words
ID: J42-Y2020
