Rh(III)-Catalyzed Imidoyl C-H Carbamylation and Cyclization to Bicyclic [1,3,5]Triazinones
Danielle N. Confair, Nathaniel S. Greenwood, Brandon Q. Mercado and Jonathan A. Ellman*
*Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States, Email: jonathan.ellmanyale.edu
D. N. Confair, N. S. Greenwood, B. Q. Mercado, J. A. Ellman, Org. Lett., 2020, 22, 8993-8997.
see article for more reactions
Rh(III) catalyzes a synthesis of bicyclic [1,3,5]triazinones from a diverse array of imines with ethyl (pivaloyloxy)carbamate. The preparation of [5,6]- and [6,6]-bicyclic heterocycles substituted with aryl, alkyl, and alkoxy groups demonstrated a broad reaction scope. The development of a three-component variant featuring in situ imine formation is also reported.
see article for more examples