Iron-Promoted Decarboxylation of Arylacetic Acids for the Synthesis of Aromatic Nitriles with Sodium Nitrite as the Nitrogen Source

Zhenpeng Shen, Wenbo Liu, Xinzhe Tian*, Zhe Zhao, Yun-Lai Ren*

*College of Science, Henan Agricultural University, Zhengzhou, Henan 450002, P. R. of China, Email: zzutxz126.com, renyunlai126.com

Z. Shen, W. Liu, X. Tian, Z. Zhao, Y.-L. Ren, Synlett, 2020, 31, 1805-1808.

DOI: 10.1055/s-0040-1707300

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Abstract

Using NaNO₂ as the nitrogen source and Fe(OTf)₃ as a promoter at 50°C, a series of arylacetic acids provides aromatic nitriles in good yields. The reaction is compatible with a broad range of functional groups.

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Key Words

aryl nitriles, nitriles, decarboxylation, sodium nitrite, iron catalysis, arylacetic acids

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ID: J72-Y2020