Iron-Promoted Decarboxylation of Arylacetic Acids for the Synthesis of Aromatic Nitriles with Sodium Nitrite as the Nitrogen Source
Zhenpeng Shen, Wenbo Liu, Xinzhe Tian*, Zhe Zhao, Yun-Lai Ren*
*College of Science, Henan Agricultural University, Zhengzhou, Henan 450002, P. R. of China, Email: zzutxz126.com, renyunlai126.com
Z. Shen, W. Liu, X. Tian, Z. Zhao, Y.-L. Ren, Synlett, 2020, 31, 1805-1808.
DOI: 10.1055/s-0040-1707300 (free Supporting Information)
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Using NaNO2 as the nitrogen source and Fe(OTf)3 as a promoter at 50°C, a series of arylacetic acids provides aromatic nitriles in good yields. The reaction is compatible with a broad range of functional groups.
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