Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H₂O: An Expedient Way to Access Alkyl Amides

Qiao Li, Hongwei Jin, Yunkui Liu*, Bingwei Zhou*

*College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China, Email: ykuiliuzjut.edu.cn, zhoubwzjut.edu.cn

Q. Li, H. Jin, Y. Liu, B. Zhou Synthesis, 2020, 52, 1841-1846.

DOI: 10.1055/s-0040-1707229

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Abstract

A convenient Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanides, and H₂O provides alkyl amides. Bench-stable NiCl₂(dppp) is able to initiate this transformation under mild reaction conditions.

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Key Words

nickel catalysis, isocyanides, alkyl halides, multicomponent reactions, amides

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ID: J66-Y2020