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Electrochemical Iodoamination of Indoles Using Unactivated Amines

Ning Lei, Yanling Shen, Yujun Li, Pan Tao, Liquan Yang, Zhishan Su and Ke Zheng*

*Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China, Email:

N. Lei, Y. Shen, Y. Li, P. Tao, L. Yang, Z. Su, K. Zheng, Org. Lett., 2020, 22, 9184-9189.

DOI: 10.1021/acs.orglett.0c03158

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An environmentally friendly electrochemical approach enables an iodoamination of various indole derivatives with a series of unactivated amines, amino acid derivatives, and benzotriazoles. This strategy was further applied in late-stage functionalization, gram-scale synthesis and radiolabeling.

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Key Words

indoles, electrochemistry

ID: J54-Y2020