Palladium-Catalyzed Amide N-C Hiyama Cross-Coupling: Synthesis of Ketones

Muhammad Aliyu Idris and Sunwoo Lee*

*Department of Chemistry Chonnam National University, Gwangju 61186, Republic of Korea, Email: sunwoochonnam.ac.kr

M. A. Idris, S. Lee, Org. Lett., 2020, 22, 9184-9189.

DOI: 10.1021/acs.orglett.0c03260

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Abstract

Pd(OAc)₂/PCy₃ catalyzes the Hiyama cross-coupling between N-acylglutarimides and arylsiloxanes in the presence of Et₃N·3HF and LiOAc to provide the corresponding arylketones in good yields. The reaction had a broad substrate scope and showed good functional group tolerance.

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Key Words

Hiyama coupling, aryl ketones

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ID: J54-Y2020