Synthesis of gem-Difluoroalkenes via Zn-Mediated Decarboxylative/Defluorinative Cross-Coupling
Hai-Wu Du, Yang Chen, Jing Sun*, Qi-Sheng Gao, He Wang and Ming-Dong Zhou*
*School of Chemistry and Materials Science, Liaoning Shihua University, Fushun 113001, P. R. China, Email: sunjinglnpu.edu.cn, mingdong.zhoulnpu.edu.cn
H.-W. Du, Y. Chen, J. Sun, Q.-S. Gao, H. Wang, M.-D. Zhou, Org. Lett., 2020, 22, 9342-9345.
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Zn mediates a decarboxylative/defluorinative alkylation of α-trifluoromethyl alkenes with N-hydroxyphthalimide esters as radical precursors. Several α-trifluoromethyl alkenes were readily coupled to a wide range of primary, secondary, and tertiary radicals, affording the desired gem-difluoroethylenes in good yields.
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