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Transition-Metal-Free Synthesis of Trifluoromethylated Furans via a Bu3P-Mediated Tandem Acylation-Wittig Reaction

Maizhan Li, Wei Zhou*

*Innovative Drug Development of Chinese Ministry of Education, College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510632, P. R. of China, Email:

M. Li, W. Zhou, Synlett, 2020, 31, 203-2038.

DOI: 10.1055/s-0040-1707263

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A highly efficient nucleophilic addition-O-acylation-intramolecular Wittig reaction of β-trifluoromethyl α,β-enones provides a set of biologically significant trifluoromethylated furans in high yields. This transition-metal-free method offers mild reaction conditions and tolerates diverse functional groups.

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Key Words

β-trifluoromethyl α,β-enones, Wittig reaction, nucleophilic addition, furans

ID: J72-Y2020