α-Alkylation of Nitriles with Primary Alcohols by a Well-Defined Molecular Cobalt Catalyst
Keshav Paudel, Shi Xu and Keying Ding*
*Department of Chemistry, Middle Tennessee State University, Murfreesboro, Tennessee 37132, United States,
Email: Keying.Ding
mtsu.edu
K. Paudell, S. Xu, K. Ding, J. Org. Chem., 2020, 85, 14980-14988.
DOI: 10.1021/acs.joc.0c01822
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Abstract
A well-defined molecular homogeneous cobalt complex catalyzes an α-alkylation of nitriles with primary alcohols in very good yields. Remarkably, this transformation is environmentally friendly and atom economical with water as the only byproduct.
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Switchable Cobalt-Catalyzed α-Olefination and α-Alkylation of Nitriles with Primary Alcohols
K. Paudel, S. Xu, K. Ding, Org. Lett., 2021, 23, 5028-5032.
Key Words
ID: J42-Y2020
