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Homogeneous Nickel-Catalyzed Sustainable Synthesis of Quinoline and Quinoxaline under Aerobic Conditions

Amreen K. Bains, Vikramjeet Singh and Debashis Adhikari*

*Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, SAS Nagar, 140306 Mohali, India, Email: adhikariiisermohali.ac.in

A. K. Bains, V. Singh, D. Adhikari, J. Org. Chem., 2020, 85, 14971-14979.

DOI: 10.1021/acs.joc.0c01819 (free Supporting Information)


Abstract

A convenient and eco-friendly nickel-catalyzed synthesis of quinoline and quinoxaline via double dehydrogenative coupling starting from 2-aminobenzyl alcohol/1-phenylethanol and diamine/diol, respectively, operates at mild reaction temperatures. The inexpensive molecularly defined catalyst can easly be regenerated under aerobic/O2 oxidation.

 

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Key Words

Quinolines, Quinoxalines, Oxygen


ID: J42-Y2020