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Easy Access to 2,4-Disubstituted Cyclopentenones by a Gold(III)-Catalyzed A3-Coupling/Cyclization Cascade

Jian Li*, Yue Xu, Xiwen Hu, Shangrong Zhu and Li Liu*

*Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Pharmacy, Changzhou University, Changzhou, 213164, China, Email: liliucczu.edu.cn

J. Li, Y. Xu, X. Hu, S. Zhu, L. Liu, Org. Lett., 2020, 22, 9478-9483.

DOI: 10.1021/acs.orglett.0c03451 (free Supporting Information)


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Abstract

A Au(III)-catalyzed isomerization-A3-coupling/cyclization cascade enables an efficient and convenient synthesis of 2,4-disubstituted cyclopentenones.

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Key Words

Cyclopentenones, Multicomponent Reactions


ID: J54-Y2020