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The Domino Chromone Annulation and a Transient Halogenation-Mediated C-H Alkenylation toward 3-Vinyl Chromones

Leiqing Fu, Zhongrong Xu, Jie-Ping Wan* and Yunyun Liu*

*College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China, Email:,

L. Fu, Z. Xu, J.-P. Wan, Y. Liu, Org. Lett., 2020, 22, 9518-9523.

DOI: 10.1021/acs.orglett.0c03548

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Reactions between readily available o-hydroxyphenyl enaminones and various alkenes enable a a step economical and general synthesis of 3-vinyl chromones.

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proposed mechanism

Key Words

chromones, TBHP

ID: J54-Y2020