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Iron(0)-Catalyzed Transfer Hydrogenative Condensation of Nitroarenes with Alcohols: A Straightforward Approach to Benzoxazoles, Benzothiazoles, and Benzimidazoles

Ramachandra Reddy Putta, Simin Chun, Seung Hyun Choi, Seok Beom Lee, Dong-Chan Oh and Suckchang Hong*

*Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea, Email:

R. R. Putta, S. Chun, S. H. Choi, S. B. Lee, D.-C. Oh, S. Hong, J. Org. Chem., 2020, 85, 15396-15405.

DOI: 10.1021/acs.joc.0c02191 (free Supporting Information)

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An iron-catalyzed hydrogen transfer strategy for the redox condensation of o-hydroxynitrobenzenes with alcohols provides a wide range of 2-substituted benzoxazoles in very good yields. Furthermore, the reaction system was successfully extended to the synthesis of benzothiazoles and benzimidazoles.

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Key Words


ID: J42-Y2020