Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Umpolung 1,4-Addition of Vinyl Bromides to Enals
Bo Ling, Wenjun Yang, Yan-En Wang and Jianyou Mao*
*School of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P.R. China, Email: ias_jymaonjtech.edu.cn
B. Ling, W. Yang, Y.-E. Wang, J. Mao, Org. Lett., 2020, 22, 9603-9608.
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NHC/palladium cooperative catalysis enables a highly stereoselective umpolung 1,4-addition of vinyl bromides to enals to provide various valuable γ,δ-unsaturated carbonyl derivatives in excellent yields. The NHC acts as both organocatalyst and ligand for palladium.
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