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Electron Donor-Acceptor Complex-Initiated Photochemical Cyanation for the Preparation of α-Amino Nitriles

Qing Xia, Yufei Li, Lan Cheng, Xin Liang, Chenlin Cao, Peng Dai, Hongping Deng, Weihua Zhang* and Qingmin Wang*

*Nanjing Agricultural University, Nanjing 210095; Nankai University, Tianjin 300071, China, Email:,

Q. Xia, Y. Li, L. Cheng, X. Liang, C. Cao, P. Dai, H. Deng, W. Zhang, Q. Wang, Org. Lett., 2020, 22, 9638-9643.

DOI: 10.1021/acs.orglett.0c03703

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An electron donor-acceptor complex-initiated α-cyanation of tertiary amines proceeds smoothly without the presence of photocatalysts and transition metal catalysts to provide various α-amino nitriles under mild conditions.

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Key Words

tetrahydroisoquinolines, photochemistry

ID: J54-Y2020