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Autocatalytic Synthesis of Thioesters via Thiocarbonylation of gem-Difluoroalkenes

Xinpeng Jiang*, Guan Wang, Zicong Zheng, Xiaohui Yu, Ye Hong, Haoqi Xia and Chuanming Yu*

*College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China, Email:,

X. Jiang, G. Wang, Z. Zheng, X. Yu, Y. Hong, H. Xia, C. Yu, Org. Lett., 2020, 22, 9762-9766.

DOI: 10.1021/acs.orglett.0c03860

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The thiocarbonylation of gem-difluoroalkenes with thiols provides acyethanethioates in good yields in the presence of water under mild conditions without the use of any additives.

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Key Words


ID: J54-Y2020