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Lanthanide Triflate Catalyzed Biginelli Reaction. One-Pot Synthesis of Dihydropyrimidinones under Solvent-Free Conditions

Yun Ma, Changtao Qian*, Limin Wang and Min Yang

*Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China

Y. Ma, C. Qian, L. Wang, M. Yang, J. Org. Chem., 2000, 65, 3864-3868.

DOI: 10.1021/jo9919052


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Abstract

By using Yb(OTf)3 as a catalyst and under solvent-free reaction conditions, the yields of the one-pot Biginelli reaction can be increased while the reaction time was shortened. In addition, the catalyst can be easily recovered and reused. It not only led to economical automation but also reduces hazardous pollution to achieve environmentally friendly processes.


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Key Words

Biginelli Reaction, multicomponent reactions, green chemistry


ID: J42-Y2000