Sterically Demanding, Water-Soluble Alkylphosphines as Ligands for High Activity Suzuki Coupling of Aryl Bromides in Aqueous Solvents
Kevin H. Shaughnessy* and Rebecca S. Booth
*Department of Chemistry, The University of Alabama, Box 870336, Tuscaloosa, Alabama 35487-0336,
Email: kshaughn
ua.edu
K. H. Shaughnessy, R. S. Booth, Org. Lett., 2001, 3, 2757-2759.
DOI: 10.1021/ol0163629
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Abstract
Pd complexes of sterically demanding, water-soluble alkylphosphines are highly active catalysts for Suzuki coupling of boronic acids with aryl bromides in aqueous solvents. High turnover numbers have been achieved under mild conditions.
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Key Words
Suzuki Coupling, Green Chemistry
ID: J54-Y2001
